Director of Clinical Imaging and Dosimetry

Director of Clinical Imaging & Dosimetry

Currently working with a clinical-stage biopharmaceutical company developing next-generation targeted radiopharmaceutical therapies for oncology. The company has a growing pipeline of radioligand therapeutics and diagnostics, with clinical programmes spanning multiple solid tumour indications.

The company is seeking a Director of Clinical Imaging & Dosimetry to lead medical physics and dosimetry activities across its radiopharmaceutical programmes. This is a newly created position, reporting to the Chief Medical Officer, and will serve as the internal authority on all matters related to imaging science, dosimetry, and radiation physics in clinical development.

If interested - keep reading.

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Key Responsibilities

Clinical Imaging & Dosimetry (Primary Focus)

• Lead all imaging and dosimetry activities within clinical trials, including protocol development, imaging manual compilation, site qualification, and data analysis.
• Read, process, and analyse clinical imaging data (DICOM files): image reconstruction, organ and tumour segmentation, MIP generation, and quantitative analysis (SUVmean, SUVmax, SUVpeak, IA/g).
• Perform and oversee dosimetry calculations using image-based and blood-based methods, including time-activity curves (TACs/TIACs), S-value based calculations, and source-to-target organ modelling.

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General Radiation Physics & Scientific Leadership

• Serve as the company's subject matter expert on radionuclide physics: decay chains, isotope-specific detection considerations, safety implications, and daughter decay products.
• Be fluent in handling different methods of activity calculation (time of injection vs. time of collection) and familiar with standardisation, calibration, and metrology.
• Evaluate and manage relationships with dosimetry vendors and imaging CROs (e.g. RAPID, ABX-CRO), including daily operational interaction and scientific oversight of deliverables.

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Preclinical Translation (Secondary Focus)

• Understand and advise on approaches used for scaling dosimetry estimates from preclinical models to humans.
• Contribute to the interpretation of preclinical biodistribution data and its translation into clinical dosimetry predictions.

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Requirements

• Essential - Hands-on experience with internal dosimetry in a clinical or clinical trial setting.
• Essential - experience many of the core job description points - dosimetry software (e.g. OLINDA, MIRD), quantitative imaging analysis, PET, SPECT/CT etc.
• Essential - Currently based in EU / CH / UK with working rights. Visa sponsorship not supported at this stage.
• Ideal - not essential - degree in Medical Physics, Nuclear Physics, Radiation Physics, Health Physics, or a closely related discipline.
• Ideal - not essential - experience working in a biotech or pharmaceutical company (hospital or academic setting is fine but clinical experience is required).
• Ideal - not essential - Track record of managing or directing dosimetry CROs/vendors in a clinical trial context.

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Compensation and Contract

• CHF: 170,000 - 230,000 Base + Bonus + LTIs.
• Contract: Permanent or Consultant/Part-Time available for the right person.
• Office Requirement: Complicated answer! Apply - if there is a good fit we will make something work.

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Human Led Recruitment

• OK…I used Claude to help me draft this but spent time on the human review.
• However no AI is used to review CVs or applications.
• My guarantee - I will feedback anyone who replies. No…I cant provide individual feedback but as a minimum I will give you a Yes or No.

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If interested in learning more - would love to hear from you. Feel free to repost / reshare to those in your network.

Charles Spence Founder, Discera Search charles@discera-search.com